Effect of Tangbi Capsules on Ultrastructure of Sciatic Nerve in Diabetic Rats / 广州中医药大学学报
Article
en Zh
| WPRIM
| ID: wpr-580092
Biblioteca responsable:
WPRO
ABSTRACT
Objective To observe the effect of Tangbi Capsules(TC)on ultrastructure of sciatic nerve in diabetic rats.Methods SD diabetic rat models were induced by one-dose intraperitoneal injection of streptozotocin(50 mg/kg).Then the diabetic rats were randomized into 5 groups: model group,high-and low-dose TC groups(in the dose of 1 and 0.5 g?kg-1?d-1 respectively),mecobalamin(250 ?g?kg-1?d-1)group,and the combination group(receiving TC 0.5 g?kg-1?d-1 and mecobalamin 250 ?g?kg-1?d-1).Meanwhile,the normal control group was also set up.After treatment for 4 weeks,the changes of utrastructure of sciatic nerve in different groups were observed under electron microscope.Results The pathological changes of sciatic nerve in diabetic rats were similar with the clinical peripheral neuropathy.The protective effect on sciatic nerve in high-dose TC group was superior to that in low-dose TC group and mecobalamin group,and the combination group had the best protective effect.Conclusion TC exerts certain protective effect on diabetic peripheral neuropathy.
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1
Base de datos:
WPRIM
Tipo de estudio:
Clinical_trials
Idioma:
Zh
Revista:
Journal of Guangzhou University of Traditional Chinese Medicine
Año:
2004
Tipo del documento:
Article