Effect of Aitongping on c-fos Gene Expression and Substance P Content in Spinal Dorsal Horn of Rats with Formalin-induced Pain / 广州中医药大学学报
Article
en Zh
| WPRIM
| ID: wpr-579084
Biblioteca responsable:
WPRO
ABSTRACT
Objective To observe the effect of Aitongping on c-fos gene expression and substance P(SP) content in spinal dorsal horn of rats with formalin-induced pain.Methods Fifty SD rats were randomized into 5 groups: blank control group,model group,tramadol group(0.06g/kg),high-and low-dose Aitongping groups(36 and 18g/kg respectively).Rats model of pain was induced by subcutaneous injection of formalin into the plantar surface of the left hind paw of rats.The fos gene expression and SP content were observed in superficial lamella of spinal dorsal horn of spinal section from the lumbar vertebrae L3 to L5 by immunohistochemical method.Results The number of neurons with fos gene expression positive and the optical density(D value) of reactants with SP expression positive were increased in the model group(P
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1
Base de datos:
WPRIM
Tipo de estudio:
Clinical_trials
Idioma:
Zh
Revista:
Journal of Guangzhou University of Traditional Chinese Medicine
Año:
2001
Tipo del documento:
Article