Pharmacokinetic study of loganin in LIUWEI DIHUANG DECOCTION~* in mice / 中草药
Zhongcaoyao
; Zhongcaoyao;(24)1994.
Article
en Zh
| WPRIM
| ID: wpr-570660
Biblioteca responsable:
WPRO
ABSTRACT
Object To study the pharmacokinetics of loganin in LIUWEI DIHUANG DECOCTION (LWDHD) in mice. Methods HPLC-UV detection was used to determine the loganin levels in biological samples. Results After ig LWDHD in mice, the plasma concentration-time course fitted well to one-compartment model with the 1st order absorption and with the following pharmacokinetic parameters; Ka= 0.04min -1, Ke=0.019 min -1, T (peak)=42.4 min, t 1/2ka=17.4 min, t 1/2ke=35.75 min. Conclusion The pharmacokinetic parameters of loganin obtained in the study may be attributed to the effect of other constituentsin the DECOCTION.
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Base de datos:
WPRIM
Idioma:
Zh
Revista:
Zhongcaoyao
Año:
1994
Tipo del documento:
Article