THE EFFECTS OF CHOLERAL TOXIN ON THE REGENERATIONOF THE RETINAL GANGLION CELLS IN GOLDEN HAMSTER / 解剖学报
Acta Anatomica Sinica
; (6)1954.
Article
en Zh
| WPRIM
| ID: wpr-569782
Biblioteca responsable:
WPRO
ABSTRACT
Objective The present study was aimed at investigating the effects of cholera toxin(CTx) on promoting the regeneration of retinal ganglion cells(RGCs) in hamster retina. Methods After optic nerve (ON) transection, an autologus sciatic nerve (attached graft, AG) was removed and sutured to the proximal stump of the ON. CT X was injected or (and) a small segment of sciatic nerve (SN) inserted intravitrously. Animals were separated into 5 groups:regenerating control group(AG groups and solution groups); AG+CT X groups; AG+SN groups; AG+CT X+SN groups; Effect and Dosage groups; Animals in the former 4 groups were allowed to survive for 2-6 weeks respectively. The regenerated RGCs were labeled retrogradely by granular blue, and the changes in number of regenerating RGCs in each retina were observed under fluorescent microscope. Results The mean numbers of regenerating RGCs in AG+CT X groups were increased and significantly higher than those in AG groups and solution groups at each time point( P
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Base de datos:
WPRIM
Idioma:
Zh
Revista:
Acta Anatomica Sinica
Año:
1954
Tipo del documento:
Article