The metastasis suppressing ability and its mechanism of calmodulin antagonist EBB in human metastatic ovarian clear cell line ES-2 / 中国药理学通报
Chinese Pharmacological Bulletin
; (12)1986.
Article
en Zh
| WPRIM
| ID: wpr-567614
Biblioteca responsable:
WPRO
ABSTRACT
Aim To investigate the potential suppressing effect of calmodulin antagonist EBB on metastasis-associated properties of human metastatic ovarian clear cell adenocarcinoma cell ES-2.Methods MTT assay was used to assess the growth inhibition of EBB on ES-2 cells.The invasive capacity and motility potential were determined by Transwell chamber assay and Wound assay.[Ca2+]i was observed under the laser scanning confocal microscopy.Results EBB inhibited the proliferation of ES-2 cells in vitro.The IC50 on ES-2 cells was(13.67?1.56)?mol?L-1.The invasive ability and motility potential of ES-2 cells were decreased after exposure to 3,7 and 14 ?mol?L-1 EBB respectively(P
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Base de datos:
WPRIM
Idioma:
Zh
Revista:
Chinese Pharmacological Bulletin
Año:
1986
Tipo del documento:
Article