Effects of omapatrilat on renal tubulointerstitial fibrosis in 5/6 subtotal nephrectomized rats / 中华肾脏病杂志
Chinese Journal of Nephrology
; (12)1994.
Article
en Zh
| WPRIM
| ID: wpr-556449
Biblioteca responsable:
WPRO
ABSTRACT
Objective To investigate the effect of vasopeptidase inhibitors (VPi) omapatrilat on renal tubulointerstitial fibrosis of 5/6 subtotal nephrectomized rats and to explore new prevention and treatment of renal lubulointerstitial fibrosis.Methods The renal subtotal ablation model was established by surgical 5/6 renal resection in male SD rats.Five animal groups included(1)STN group (subtotal nephreclomy); (2)Omap 10 mg group (10 mg?kg-1?d-1); (3)Omap 40 mg group (40 mg?kg-1?d-1) ; (4)Sham group and (5)Nornial control. Systolic arterial BP and renal function were measured periodically.Animals were sacrificed at the end of the 12th week after operation. Tubulointerstitial injury was scored semiquantitatively by morphological analysis (HE, Masson, PAS and PASM stain). Results Significant tubulointerstitial injury was noted in the STN group compared with normal group and sham group (P
Texto completo:
1
Base de datos:
WPRIM
Tipo de estudio:
Prognostic_studies
Idioma:
Zh
Revista:
Chinese Journal of Nephrology
Año:
1994
Tipo del documento:
Article