Study on the mechanism of therapeutic effect of "Yichantang" in the treatment of Parkinson disease / 解放军医学杂志
Article
en Zh
| WPRIM
| ID: wpr-555303
Biblioteca responsable:
WPRO
ABSTRACT
Objective To explore the mechanism of therapeutic effect of Yichantang in the treatment of Parkinson′s disease (PD). Methods A rat model of PD was replicated. The experimental animals were divided into a normal control group,a normal saline control group and a Yichantang group. Changes in the rats' behavior pattern was obrerved. Using the technique of intracerebral dialysis,the content of catecholamine like substances in the nigral extracellular fluid(NECF)was measured by means of high performance liquid chromatography(HPLC). Changes in the affinity and quantity of M and DA receptors were determined too. Results Yichantang markedly improved the rats' rotation behavior,and enhanced the Bmax and KD of DA and M receptors in the brain tissues on the side of lesion. The levels of DOPAC,HVA,DA and 5-HT in the NECF of the side of lesion in the Yichantang group were significantly higher than that of the normal saline group ( P
Texto completo:
1
Base de datos:
WPRIM
Idioma:
Zh
Revista:
Medical Journal of Chinese People's Liberation Army
Año:
2001
Tipo del documento:
Article