Impact of the CD4~+CD25~(nt/hi)CD127~(lo) regulatory T cells on the immune status and disease progression in HIV-1 infected individuals / 中国免疫学杂志
Chinese Journal of Immunology
; (12)1999.
Article
en Zh
| WPRIM
| ID: wpr-545768
Biblioteca responsable:
WPRO
ABSTRACT
Objective:To investigate the impact of the CD4+CD25nt/hiCD127lo regulatory T cell subset frequency on the immune status and disease progression of Chinese HIV-1 infected individuals.Methods:83 untreated HIV-infected individuals and 312 healthy control individuals of four distinct age groups were enrolled in the research. The CD4+ T cell absolute counts, phenotypes and frequency determination of CD4+CD25nt/hiCD127lo Regulatory T cell subsets was performed on freshly obtained whole blood samples by 3-color immune staining flow cytometry. The HIV-1 specific cellular immune function was test at single cell level by ELISpot. The corresponding plasma viral load was determined by NASBA.Results:The frequency of peripheral CD4+CD25nt/hiCD127lo regulatory T cells of HIV infected individuals in distinct disease progression status was dissimilar in China , and significantly increased in contrast to the healthy controls(P
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Base de datos:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Immunology
Año:
1999
Tipo del documento:
Article