NK cells are involved in OVA induced asthma in murine / 中国免疫学杂志
Chinese Journal of Immunology
; (12)2001.
Article
en Zh
| WPRIM
| ID: wpr-545577
Biblioteca responsable:
WPRO
ABSTRACT
Objective:To investigate the changes of lung lymphocytes in OVA induced murine asthma model,and study the involvement of NK cells in this process.Methods:C57BL/6J(B6) mice were induced to develop asthma by intrapenitoneal injection of OVA with alum as adjuvant, and then inhalation of nebulized OVA. After collecting serum and Bronchoalveolar Lavage Fluid(BALF),IL-4 level was determined by ELISA. The kinetics of pulmonary lymphocyte recruitment and cytokine release were detected by flow cytometry.Results:IL-4 expression increased in BALF after OVA nebulization, while there was no significant difference in serum. IFN-?,IL-4+NK cells accumulation in lung parenchymal tissues,and exhibited an evident NK2 shift in mice with asthma.Conclusion:NK cell involved in OVA-induced mouse asthma and NK2 shift accompany with Th2, indicating that NK2 played an important role in this process.
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Base de datos:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Immunology
Año:
2001
Tipo del documento:
Article