Regulation of tazarotene on HB-EGF in hyperproliferative epidermis of psoriasis / 西安交通大学学报(医学版)
Article
en Zh
| WPRIM
| ID: wpr-540813
Biblioteca responsable:
WPRO
ABSTRACT
Objective To investigate the mechanism of tazarotene in active psoriasis vulgaris. Methods HB-EGF mRNA in active psoriatic lesions before and 10 days after the treatment with tazarotene was detected by hybridization in situ. Results There was nearly no expression of HB-EGF mRNA in psoriatic lesions (9.1%); after the treatment with tazarotene, there was expression of HB-EGF not only in basal layer (95.5%), but also focal expression in suprabasal layers of epidermis (77.3%). Conclusion Tazarotene can inhibit proliferation and induce apoptosis of keratinocytes though upregulating expression of HB-EGF in psoriatic epidermis.
Texto completo:
1
Base de datos:
WPRIM
Idioma:
Zh
Revista:
Journal of Xi'an Jiaotong University(Medical Sciences)
Año:
1982
Tipo del documento:
Article