Ultrastructural changes of external iliac arteries in hyperhomocysteinemia rabbits with endothelial dysfunction / 中华超声影像学杂志
Chinese Journal of Ultrasonography
; (12)2003.
Article
en Zh
| WPRIM
| ID: wpr-538824
Biblioteca responsable:
WPRO
ABSTRACT
Objective Through transmission electron microsco pe to observe the ultrastructural changes in external iliac arteries of hyperhomocysteinemia rabbits with endothelial dysfunction.Methods Eighteen rabbits were randomized into two groups (n=9 per group).Control group (N group) was poured water into stomach,Methionine group (M group) were poured L-methionine ( 5.0 g/kg weight) into stomach.Endothelium-dependent dilation (EDD),endothelium-independent dilation (EID) were examined by high resolution ultrasound at 0,4,8,12,24 h,at same time and external iliac arteries were observed by transmission electron microscope after 24 h.Results ① In acute hyperhomocysteinemia,EDD of external iliac artery in M group was time-dependent reduced more significantly than that in N group,but EID was not affected. ② Under transmission electron microscope,external iliac arteries of rabbits showed endothelial cells dropping,mitochondrion swelling in endothelial cells and smooth muscle cells,internal elastic lamina disruption,migration of smooth muscle cell to subendothelial space.Conclusions In hyperhomocysteinemia,homocysteine could lead to endothelial dysfunction in rabbits and ultrastructural damage of endothelial cells,smooth muscle cells and internal elastic lamina.High resolution ultrasound could find the endothelial dysfunction accurately.
Texto completo:
1
Base de datos:
WPRIM
Tipo de estudio:
Clinical_trials
Idioma:
Zh
Revista:
Chinese Journal of Ultrasonography
Año:
2003
Tipo del documento:
Article