Advances on studies of AIDS pathogenesis and new strategies for drug and vaccine development / 中国病理生理杂志
Chinese Journal of Pathophysiology
; (12)1999.
Article
en Zh
| WPRIM
| ID: wpr-531117
Biblioteca responsable:
WPRO
ABSTRACT
A breakthrough has recently been made in the studies on pathogenesis of HIV disease,which result in some new theories.New strategies for HIV drug and vaccine development are emerging in the impact of these new understandings.The intestinal infection hypothesis proposes that HIV disease can be regarded as some kind of infectious disease of gut immune system as the major HIV infection is located in intestine.The acute catastrophe hypothesis suggests that the subsequent pathological changes are the fallout from a mucosal catastrophe of acute intestinal HIV infection,in which the majority of CD4+ T cells are deleted due to infection.The general immune overactivation hypothesis proposes that the general immune overactivation is harmful to patient as it increases the cell susceptibility to HIV infection and supportiveness of HIV replication.The host proteins related to HIV replication can be new targets for HIV drug discovery.The mucosal vaccine strategies,which attempt to induce HIV specific neutralizing antibodies on mucosal surface may be the first choice in development of prophylactic HIV vaccines.Induction of tolerance may be one of the strategies for HIV therapeutic vaccines because HIV disease can be regarded as autoimmune disease caused by HIV infection.
Texto completo:
1
Base de datos:
WPRIM
Tipo de estudio:
Etiology_studies
Idioma:
Zh
Revista:
Chinese Journal of Pathophysiology
Año:
1999
Tipo del documento:
Article