Determination of Chicoric Acid in Three Different Pharmaceutical Dosage Forms by RP-HPLC / 中国药房
China Pharmacy
; (12)2005.
Article
en Zh
| WPRIM
| ID: wpr-530901
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVE:To determine the contents of chicoric acid in three different pharmaceutical dosage forms by RP-HPLC.METHODS:Samples were determined on VP-ODS C18,with the mobile phase consisted of methanol-1% acetic acid-tetrahydrofuran(33∶62∶5) with flow rate at 1.0 mL?min-1,UV detection wavelength at 327 nm,column temperature at 30 ℃ and sample size at 20 ?L.RESULTS:The linear range of chicoric acid was 0.398 72～3.987 2 ?g(r=0.999 8).The average recoveries of the oral liquid,capsules,and tablets were 99.85%(RSD=0.98%),102.50%(RSD=1.84%),and 100.50%(RSD=1.69%),respectively.CONCLUSION:This method is accurate,reproducible,specific,and suitable for the content determination of chicoric acid.
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Base de datos:
WPRIM
Idioma:
Zh
Revista:
China Pharmacy
Año:
2005
Tipo del documento:
Article