Preparation of Diclofenac Sodium Controlled Release Pellets and Study on the Release Behaviour / 中国药房
China Pharmacy
; (12)2001.
Article
en Zh
| WPRIM
| ID: wpr-523351
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVE:To prepare diclofenac sodium controlled release pellets and investigate the mechanism of re?lease.METHODS:Single-factor method was used to investigate the influence of the composition of solvent system in coating solution,the concentration of coating material,porogenic agent and plastifier on the release rate of drug.RESULTS:When the concentration of coating material and the proportion of water increased,the release rate of pellets was increased;the release rate was further increased with PVP K30 added.CONCLUSION:The pellets belongs to the matrix-coating pellets,and the release mechanism varies with the change of coating thickness.
Texto completo:
1
Base de datos:
WPRIM
Idioma:
Zh
Revista:
China Pharmacy
Año:
2001
Tipo del documento:
Article