A new synthetic process of dapagliflozin / 中国药科大学学报
Journal of China Pharmaceutical University
; (6): 42-45, 2017.
Article
en Zh
| WPRIM
| ID: wpr-514218
Biblioteca responsable:
WPRO
ABSTRACT
This paper describes a practical process for a SGLT2 inhibitor dapagliflozin. The target product was synthesized from 1-chloro-2-( 4-ethoxybenzyl)-4-iodobenzene and 2, 3, 4, 6-tetra-O-acetyl-alpha-D-glucopyranosyl bromide by iodine-magnesium exchange, and coupling and acetyl removing reactions with the total yield of 50%. This practical process highlights fewer reaction steps, less waste and mild reaction conditions.
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Base de datos:
WPRIM
Idioma:
Zh
Revista:
Journal of China Pharmaceutical University
Año:
2017
Tipo del documento:
Article