Activation of small conductance Ca2+ activated K+ channelin spinal cord could inhibit morphine-induced hyperalgesia in mice / 中国药理学通报
Chinese Pharmacological Bulletin
; (12): 547-551, 2017.
Article
en Zh
| WPRIM
| ID: wpr-511282
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WPRO
ABSTRACT
Aim To explore the effect of activated SK channels(small conductance Ca2+-activated K+ channels) on morphine-induced hyperalgesia in the spinal cord in mice.Methods Adult C57BL6/N male mice were chosen to establish the model of morphine-hyperalgesia.The changes of tail withdrawal latency(TWL), mechanical withdrawal threshold(MWT) and the threshold of visceral pain were observed after intrathecal 1-EBIO, the agonist of SK channels.Results Compared with the control group, TWL, MWT and the threshold of visceral pain were decreased after morphine injection.After intrathecal 1-EBIO, the TWL, MWT and visceral pain threshold were increased.The level of spinal membrane SK2 expression in morphine-treated mice was decreased compared with that of control group.After intrathecal 1-EBIO, the level of spinal membrane SK2 expression was increased.Conclusion SK channels in the spinal cord are involved in morphine-induced hyperalgesia in mice.
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WPRIM
Idioma:
Zh
Revista:
Chinese Pharmacological Bulletin
Año:
2017
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Article