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Effect of rhIL-24 combined with DDP on expression of apoptosis-related genes in human lung adenocarcinoma A549/DDP cells using GeXP / 中国免疫学杂志
Chinese Journal of Immunology ; (12): 186-189, 2017.
Article en Zh | WPRIM | ID: wpr-508292
Biblioteca responsable: WPRO
ABSTRACT
Objective:To investigate the change of apoptosis-associated genes in human lung adenocarcinoma cell lines A549/DDP cells,which were induced by the recombinant human interleukin-24(rhIL-24) combined with Cisplatin (DDP). Methods: Six genes expression level by GeXP genetic analysis system at the same time,after rhIL-24,DDP and rhIL-24+DDP were used to intervene in A549/DDP cells. Results:rhIL-24 could induce Bax gene,Caspase3 gene and Rb gene transcription up regulation;Bcl-2 gene and survivin gene transcription down regulation. But no regular change in the genes expression level of P53. Bax,Survivin and Rb were more obviously changed after rhIL-24 combined with DDP. Conclusion: RhIL-24 can induce apoptosis of A549/DDP cells through upregulated the genes expression level of Bax,Caspase3,Rb and down regulated of Bcl-2,Survivin.
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Texto completo: 1 Base de datos: WPRIM Idioma: Zh Revista: Chinese Journal of Immunology Año: 2017 Tipo del documento: Article
Texto completo: 1 Base de datos: WPRIM Idioma: Zh Revista: Chinese Journal of Immunology Año: 2017 Tipo del documento: Article