Contrasting Roles of Different Endoglin Forms in Atherosclerosis
Immune Network
; : 237-240, 2014.
Article
en En
| WPRIM
| ID: wpr-50690
Biblioteca responsable:
WPRO
ABSTRACT
Endoglin (also known as CD105 or TGF-beta type III receptor) is a co-receptor involved in TGF-beta signaling. In atherosclerosis, TGF-beta signaling is crucial in regulating disease progression owing to its anti-inflammatory effects as well as its inhibitory effects on smooth muscle cell proliferation and migration. Endoglin is a regulator of TGF-beta signaling, but its role in atherosclerosis has yet to be defined. This review focuses on the roles of the various forms of endoglin in atherosclerosis. The expression of the two isoforms of endoglin (long-form and short-form) is increased in atherosclerotic lesions, and the expression of the soluble forms of endoglin is upregulated in sera of patients with hypercholesterolemia and atherosclerosis. Interestingly, long-form endoglin shows an atheroprotective effect via the induction of eNOS expression, while short-form and soluble endoglin enhance atherogenesis by inhibiting eNOS expression and TGF-beta signaling. This review summarizes evidence suggesting that the different forms of endoglin have distinct roles in atherosclerosis.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Factor de Crecimiento Transformador beta
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Progresión de la Enfermedad
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Isoformas de Proteínas
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Miocitos del Músculo Liso
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Aterosclerosis
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Hipercolesterolemia
Límite:
Humans
Idioma:
En
Revista:
Immune Network
Año:
2014
Tipo del documento:
Article