Relationship between RAD51 Polymorphism and Therapeutic Efficacy of Cisplatin Chemotherapy in Cervical Cancer Patients / 中国药房
China Pharmacy
; (12): 3220-3222, 2015.
Article
en Zh
| WPRIM
| ID: wpr-501002
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVE:To observe the effects of RAD51 gene polymorphism on cancer prognosis and its relationship with therapeutic efficacy of cisplatin chemotherapy in patients with cervical cancer. METHODS:193 cervical cancer patients were selected and genotyped by TaqmanTM genotyping method. Therapeutic efficacy and survival period were observed in cisplatin chemotherapy combined with radiotherapy. RESULTS:The mean survival rate and therapeutic efficacy was significantly correlated with RAD51 genotype. The patients carrying the T gene had better response to drugs,compared to patients with type GG (P<0.05),and the average survival rate significantly increased(P<0.05). CONCLUSIONS:Genetic variation in RAD51 have obvious influence on the prognosis of cervical cancer chemotherapy. Therefore,RAD51 G172T genotypes give effective prognosis information about cervical cancer patients who received cisplatin chemotherapy.
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Base de datos:
WPRIM
Idioma:
Zh
Revista:
China Pharmacy
Año:
2015
Tipo del documento:
Article