The clinical analysis of fulminant Wilson's disease in patients with hepatitis B virus infection: a report of 13 cases / 中华内科杂志
Chinese Journal of Internal Medicine
; (12): 628-630, 2016.
Article
en Zh
| WPRIM
| ID: wpr-497011
Biblioteca responsable:
WPRO
ABSTRACT
To analyze the clinical features and prognosis of fulminant Wilson's disease (FWD) in patients with hepatitis B virus (HBV) infection.Twenty-seven patients were enrolled in Guangzhou Eighth People's Hospital from 2005 to 2015,including 13 FWD patients with HBV infection and 14 FWD patients without HBV infection.Clinical efficacy and survival rate were evaluated.Baseline biochemical data in two groups were comparable(P ＞ 0.05),including total bilirubin,prothrombin activity,serum albumin,alpha fetal protein,alanine transaminase,ceruloplasmin and 24 hours urine copper.Treatment in FWD group with HBV infection was ineffective,including 9(9/13) deaths and 4(4/13) patients receiveing liver transplants.However,7 (7/14) cases in the other group did not response to the treatment,including 6 (6/14) deaths and 1 (1/14)patient receiving liver transplant.The prognosis in the two groups is significantly different(P =0.006),which is much worse in FWD patients with HBV infection.
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Base de datos:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Internal Medicine
Año:
2016
Tipo del documento:
Article