Expression and significance of IL-37 and proinflammatory cytokines in peripheral blood of patients with moderate to severe psoriasis vulgaris before and after treatment / 实用医学杂志
The Journal of Practical Medicine
; (24): 1261-1264, 2016.
Article
en Zh
| WPRIM
| ID: wpr-492105
Biblioteca responsable:
WPRO
ABSTRACT
Objective To explore the expression alteration and significance of inteleukin (IL)-37 in pso-riasis valguris (PV) patients. Methods Patients with PV had been treated with oral acitretin for 8 weeks. PASI score, ELISA and qRT-PCR were used to exam the data of 38 patients (PV group) and 32 controls (control group). Results IL-37 in PV group was significantly higher than that in control group (P 0.05) but decreased obviously after 8 weeks(P < 0.001). Signif-icant correlations existed among PASI scores, IL-37, IFN-γ and IL-17, as well as among IL-37 and IFN-γ, IL-17 (P < 0.05). Conclusions The increase of IL-37 is relevant to PV development and is associated with pa-tients’ conditions, IFN-γ and IL-17 but the alteration of IL-37 is not related with IL-4.
Texto completo:
1
Base de datos:
WPRIM
Idioma:
Zh
Revista:
The Journal of Practical Medicine
Año:
2016
Tipo del documento:
Article