Determination of the Related Substances in Nortriptyline Hydrochloride by HPLC / 中国药师
China Pharmacist
; (12): 399-401, 2016.
Article
en Zh
| WPRIM
| ID: wpr-487030
Biblioteca responsable:
WPRO
ABSTRACT
Objective: To establish a determination method for the related substances in nortriptyline hydrochloride by HPLC. Methods:An Agilent C18 (250 mm × 4. 6 mm,5 μm) column was adopted with a mobile phase consisting of acetonitrile-0. 2% trieth-ylamine(pH 3. 0)(34 ∶66). The flow rate was 1. 0 ml·min-1, the detection wavelength was set at 210 nm, the column temperature was 40℃ and the injection volume was 20 μl. Results:The resolutions of the related substances were acceptable. The detection limit and the quantitation limit of the samples was 0. 40 ng and 1. 35 ng, respectively. Conclusion: The method is sensitive, accurate and specific, and can be used to determine the related substances in nortriptyline hydrochloride.
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Base de datos:
WPRIM
Idioma:
Zh
Revista:
China Pharmacist
Año:
2016
Tipo del documento:
Article