Determination of Enantiomer in Rivaroxaban by HPLC / 中国药师
China Pharmacist
; (12): 1629-1631, 2014.
Article
en Zh
| WPRIM
| ID: wpr-475808
Biblioteca responsable:
WPRO
ABSTRACT
Objective:To establish a method for the determination of enantiomer in rivaroxaban by HPLC. Methods:A Chiralpak IA column (250 mm × 4. 6 mm, 5 μm) was used with the mobile phase of 100% methanol. The flow rate was 1. 0 ml·min-1 . The detection wavelength was set at 250 nm and the column temperature was 40℃. Results:The resolution of rivaroxaban and the enanti-omer was above 2. 0. The linear range of them was 0. 5-1 000. 00 μg·ml-1(r=0. 999 9). The detection limit of the enantiomer was 0. 17ng and the average recovery was 102. 9% with RSD of 1. 54%(n=6). Conclusion:The method is accurate and rapid, and suit-able for the determination of the enantiomer in rivaroxaban.
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Base de datos:
WPRIM
Idioma:
Zh
Revista:
China Pharmacist
Año:
2014
Tipo del documento:
Article