Progress on Notch signaling pathway in the B-cell malignancies / 白血病·淋巴瘤
Journal of Leukemia & Lymphoma
; (12): 439-441, 2012.
Article
en Zh
| WPRIM
| ID: wpr-472670
Biblioteca responsable:
WPRO
ABSTRACT
The Notch signaling pathway is a highly conserved classical developmental pathway,which plays a critical role in cell-fate decision by modulating proliferation, differentiation and apoptosis. There is increasing evidence that abnormal Notch pathway is correlated with occurrence and development of many tumors. Notch signaling plays dual roles in a wide range of B-cell malignancies. It serves as either an oncogene or a tumor suppressor. Notch signaling pathway may be a novel target for B-cell malignancies therapy.
Texto completo:
1
Base de datos:
WPRIM
Idioma:
Zh
Revista:
Journal of Leukemia & Lymphoma
Año:
2012
Tipo del documento:
Article