Biological functions of alternative polyadenylation / 军事医学
Military Medical Sciences
; (12): 393-397, 2015.
Article
en Zh
| WPRIM
| ID: wpr-463466
Biblioteca responsable:
WPRO
ABSTRACT
Alternative polyadenylation ( APA) is a widespread phenomenon and an important layer of gene regulation . APA contributes to the complexity of the transcriptome by allowing a single gene to encode multiple mRNA isoforms that dif -fer either in their coding sequence or in their 3′untranslated regions (3′UTR).The length of the 3′UTR can affect the sta-bility, localization and efficiency of the messenger RNAs ( mRNAs) by altering binding sites of RNA binding proteins or mi-croRNAs(miRNAs).The polyadenylation process , mechanisms governing APA and biological consequences resulting from APA are only starting to be deciphered .Here, we review the research progress in APA .
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1
Base de datos:
WPRIM
Idioma:
Zh
Revista:
Military Medical Sciences
Año:
2015
Tipo del documento:
Article