Study on Quality Standard for Tangzhixiao Capsules / 中国药师
China Pharmacist
; (12): 2136-2138, 2014.
Article
en Zh
| WPRIM
| ID: wpr-458842
Biblioteca responsable:
WPRO
ABSTRACT
Objective:To establish the quality standard for Tangzhixiao capsules. Methods: The qualitative identification of Salvia miltiorrhiza,Atractylodes and Hawthorn was detected by TLC, and the quantitative determination of salvianolic acid B was determined by HPLC. The HPLC determination was performed on a YMC-Triart C18 (250 mm × 4. 6 mm, 5μm ) column with the mobile phase consisted of acetonitrile-0. 1% phosphoric acid (24∶ 76) at the flow rate of 1. 0 ml·min-1 , the column temperature was 30℃ and the detection wavelength was set at 286 nm. Results: The TLC spots were fairly clear, and the negative samples showed no interference. The concentration of salvianolic acid B within the range of 0. 012-0. 120 mg·ml -1 was linear with peak area(r = 0. 999 5), the average recovery was 100. 06% and RSD was 0. 83%(n = 6). Conclusion: The method is accurate, reliable and reproducible, which can be used in the quality control of Tangzhixiao capsules.
Texto completo:
1
Base de datos:
WPRIM
Tipo de estudio:
Qualitative_research
Idioma:
Zh
Revista:
China Pharmacist
Año:
2014
Tipo del documento:
Article