Effects of ethanol extracts of Panax notoginseng on liver metastasis of B16 melanoma grafted in mice / 中西医结合学报
Journal of Integrative Medicine
; (12): 500-3, 2006.
Article
en Zh
| WPRIM
| ID: wpr-449572
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVE: To observe the effects of ethanol extracts of Panax notoginseng on the tumor and the liver metastasis in experimental mice grafted with B16 melanoma. METHODS: B16 melanoma was transplanted in the spleen of C57BL/6 mice. The effects of different doses of ethanol extracts of Panax notoginseng on the inhibition rate of spleen tumors and the liver metastasis were observed respectively. RESULTS: The high-, medium-, and low-doses of the extracts and the interferon-alpha (IFN-alpha) can improve the quality of life of the experimental mice. The weights of spleen tumor were lower in the low- and medium-dose extracts-treated groups and the IFN-alpha-treated group than that in the normal saline (NS)-treated group (P<0.05 or P<0.01). The liver metastasis was less in the low- and medium-dose extracts-treated groups and the IFN-alpha-treated group than that in the NS-treated group (P<0.01). CONCLUSION: The ethanol extracts of Panax notoginseng can improve the quality of life of the experimental mice and inhibit the growth of tumor and the liver metastasis.
Texto completo:
1
Base de datos:
WPRIM
Aspecto:
Patient_preference
Idioma:
Zh
Revista:
Journal of Integrative Medicine
Año:
2006
Tipo del documento:
Article