Effect of Tangshenning on Renal Function and LOX-1 mRNA Expression in Early DN Rats Model / 中国药师
China Pharmacist
; (12): 709-712, 2014.
Article
en Zh
| WPRIM
| ID: wpr-448478
Biblioteca responsable:
WPRO
ABSTRACT
Objective:To observe the effect of Tangshenning on renal function and LOX-1 mRNA expression in the kidney of early diabetic nephropathy rats model. Methods:Early diabetic nephropathy rats model was made with high fat diet, STZ and unilateral ne-phregtomy. After the 12-week drug intervention, the rats were sacrificed, the kidneys were removed and the mRNA expressions of LOX-1 in the kidney were observed by the method of RT-PCR. Results:Early diabetic nephropathy rats model was successfully made by the triple-modeling method. The mRNA expression of LOX-1 in the kidney was significantly increased, and Tangshenning could low-er the expression of LOX-1 in the kidney in a dose-dependent manner. Conclusion:The abnormal expression of LOX-1 could be one of the mechanisms for diabetic nephropathy. Tangshening has good kidney protective effect through decreasing LOX-1 abnormal expression in the kidneys, which deserves further research.
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Base de datos:
WPRIM
Idioma:
Zh
Revista:
China Pharmacist
Año:
2014
Tipo del documento:
Article