The Differentiation of Malignant and Benign Musculoskeletal Tumors by F-18 FDG PET/CT Studies: Determination of maxSUV by Analysis of ROC Curve / 핵의학분자영상
Nuclear Medicine and Molecular Imaging
; : 553-560, 2007.
Article
en Ko
| WPRIM
| ID: wpr-44656
Biblioteca responsable:
WPRO
ABSTRACT
PURPOSE: We evaluated the standard uptake value (SUV) of F-18 FDG at PET/CT for differentiation of benign from malignant tumor in primary musculoskeletal tumors. MATERIALS AND METHODS: Forty-six tumors (11 benign and 12 malignant soft tissue tumors, 9 benign and 14 malignant bone tumors) were examined with F-18 FDG PET/CT (Discovery ST, GE) prior to tissue diagnosis. The maxSUV(maximum value of SUV) were calculated and compared between benign and malignant lesions. The lesion analysis was based on the transverse whole body image. The maxSUV with cutoff of 4.1 was used in distinguishing benign from malignant soft tissue tumor and 3.05 was used in bone tumor by ROC curve. RESULTS: There was a statistically significant difference in maxSUV between benign (n=11; maxSUV 3.4+/-3.2) and malignant (n=12; maxSUV 14.8+/-12.2) lesions in soft tissue tumor (p=0.001). Between benign bone tumor (n=9; maxSUV 5.4+/-4.0) and malignant bone tumor (n=14; maxSUV 7.3+/-3.2), there was not a significant difference in maxSUV. The sensitivity and specificity for differentiating malignant from benign soft tissue tumor was 83% and 91%, respectively. There were four false positive malignant bone tumor cases to include fibrous dysplasia, Langerhans-cell histiocytosis (n=2) and osteoid osteoma. Also, one false positive case of malignant soft tissue tumor was nodular fasciitis. CONCLUSION: The maxSUV was useful for differentiation of benign from malignant lesion in primary soft tissue tumors. In bone tumor, the low maxSUV correlated well with benign lesions but high maxSUV did not always mean malignancy.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Osteoma Osteoide
/
Sarcoma
/
Neoplasias de los Tejidos Blandos
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Imagen Corporal
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Neoplasias Óseas
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Histiocitosis de Células de Langerhans
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Curva ROC
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Sensibilidad y Especificidad
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Diagnóstico
/
Fascitis
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Idioma:
Ko
Revista:
Nuclear Medicine and Molecular Imaging
Año:
2007
Tipo del documento:
Article