Histiocytic necrotizing lymphadenitis / 临床与实验病理学杂志
Chinese Journal of Clinical and Experimental Pathology
; (12): 117-119, 2001.
Article
en Zh
| WPRIM
| ID: wpr-433902
Biblioteca responsable:
WPRO
ABSTRACT
Purpose To describe clinicopathological and immunophenotypic features of 10 cases of histiocytic necrotizing lymphadenitis (HNL). Methods HE sections of 11 lymph node biopsies were re-examined. Immunophenotyping and detection of apoptotic DNA fragments were performed using S-P and TUNEL methods, respectively. Results Five cases have been diagnosed as non-Hodgkin lymphoma. Histologically variable-sized discrete or confluent nodules were seen in the paracortex, especially in the interfollicular area, which were composed of proliferative pleomorphic histiocytes, transformed lymphocytes, and karyorrhectic debris. Immunohistochemistry revealed CD3+ and CD45RO+ for lymphocytes, Mac387+ and/or CD68+ for histiocytes, and no expression for CD15,CD30 and CD20 in the lesions. Conclusions The presence of pleomorphic histiocytes, transformed T-cells, and karyorrhectic debris in the biopsy of lymph nodes, together with the absence of neutrophils support the diagnosis of HNL.
Texto completo:
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Base de datos:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Clinical and Experimental Pathology
Año:
2001
Tipo del documento:
Article