Characteristic analysis of monoblastic sarcoma cutis preceding acute monoblastic leukemia / 中华皮肤科杂志
Chinese Journal of Dermatology
; (12): 752-753, 2012.
Article
en Zh
| WPRIM
| ID: wpr-420911
Biblioteca responsable:
WPRO
ABSTRACT
A 1-year-old boy developed multiple skin-colored nodules on the forehead and extremities when he was 4 months old.Physical examination revealed that his general condition was well with no hepatomegaly,splenomegaly,lymphadenectasis,testicle abnormality or gingival hypertrophy.Pathologically,the epidermis was normal,while the dermis and subcutaneous tissue were diffusely infiltrated with medium-to large-sized deformed cells,which had a small amount of cytoplasm,oval nucleus,irregular shape and fine chromatin.Some infiltrating cells had nuclear groove and nucleoli.Immunohistochemical studies showed that the tumor cells were positive for S-100 protein,CD56,CD123,CD163,CD68,Ki-67 (40％),weakly positive for CD4 (some),but negative for myeloperoxidase,CD1,CD21.Bone marrow smears showed a 24.5％ infltration by monoblasts and promonocytes.A diagnosis of monoblastic sarcoma cutis preceding acute monoblastic leukemia was made.
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Base de datos:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Dermatology
Año:
2012
Tipo del documento:
Article