Mechanism of polarity proteins regulate tumorigenesis / 国际肿瘤学杂志
Journal of International Oncology
; (12): 179-182, 2012.
Article
en Zh
| WPRIM
| ID: wpr-418480
Biblioteca responsable:
WPRO
ABSTRACT
Epithelial architecture is formed in tissues and organs when groups of epithelial cells are organized into polarized structures.The epithelial function as well as signaling across the epithelial layer is organized by polarity proteins.Epithelial polarity complexes form and regulate epithelial integrity.Polarity proteins establish and maintain cell polarity,regulate tight junctions and adherens junctions.Polarity proteins act as neoplasms suppressors in mammals and interact with oncogenes,disrupt cell polarity,induce tumorigenesis.Therefore,polarity mechanisms of epithelial cell could therapeutic targets for clinical therapy.
Texto completo:
1
Base de datos:
WPRIM
Idioma:
Zh
Revista:
Journal of International Oncology
Año:
2012
Tipo del documento:
Article