The neuroprotective effect of colloids in forebrain ischemia model
Anesthesia and Pain Medicine
; : 338-342, 2012.
Article
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| WPRIM
| ID: wpr-41600
Biblioteca responsable:
WPRO
ABSTRACT
BACKGROUND: The aim of this study was to investigate the neuroprotective effects of colloids (albumin and pentastarch) after forebrain global ischemia in rats. METHODS: Thirty male Sprague-Dawley rats were randomly assigned to three groups; control, albumin and pentastarch group (each n = 10). Forebrain ischemia was induced by bilateral common carotid artery occlusion plus hemorrhagic hypotension. The control group received no treatment. The albumin group received 5 ml/kg of 20% albumin after ischemia. The pentastarch group received same volume of albumin after ischemia. Histologic outcomes were measured at 7 days after ischemia in CA1 pyramidal cells of the rat hippocampus. RESULTS: The mean percentage of viable cells in the hippocampal CA1 area was significantly higher in the albumin (47%) compared with the control group (33%) or pentastarch group (33%) (P = 0.001). The percentage of apoptotic cells was significantly lower in the albumin (30%) group than that in the pentastarch (44%) or control group (49%) (P = 0.006). CONCLUSIONS: This study shows that albumin can improve histologic outcomes after forebrain global ischemia compared with pentastarch.
Palabras clave
Texto completo:
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Base de datos:
WPRIM
Asunto principal:
Isquemia Encefálica
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Derivados de Hidroxietil Almidón
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Prosencéfalo
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Ratas Sprague-Dawley
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Arteria Carótida Común
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Células Piramidales
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Coloides
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Fármacos Neuroprotectores
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Hipocampo
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Hipotensión
Límite:
Animals
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Humans
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Male
Idioma:
En
Revista:
Anesthesia and Pain Medicine
Año:
2012
Tipo del documento:
Article