The role of cyclophilin A in the development of abdominal aortic aneurysm / 国际外科学杂志
International Journal of Surgery
; (12): 270-274, 2011.
Article
en Zh
| WPRIM
| ID: wpr-414719
Biblioteca responsable:
WPRO
ABSTRACT
Abdominal aortic aneurysms (AAA) is one kind of common vascular disease. Inflammation and matrix degradation in the vasculature are crucial for AAA formation, key mechanism of which include vascular smooth muscle cell(VSMC) senescence, oxidative stress, increased local production of proinflammatory cytokines, and increased activities of matrix metalloproteinase (MMPs). Cyp A, the member of cyclophilins,has a variety of physiological functions. It is highly expressed in VSMC, and plays an important role in the development of AAA, making it a new therapeutic target for such disease.
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1
Base de datos:
WPRIM
Idioma:
Zh
Revista:
International Journal of Surgery
Año:
2011
Tipo del documento:
Article