Experimental study on therapeutic effects of Ginsenoside on Alzheimer's disease / 中国综合临床
Clinical Medicine of China
; (12): 680-682, 2008.
Article
en Zh
| WPRIM
| ID: wpr-399638
Biblioteca responsable:
WPRO
ABSTRACT
Objective To study the effects of ginsenoside on expression of inducible nitric oxide synthase and concentration of NO in THP-1 induced by amyloid beta(Aβ) in Alzheimer's disease. Methods The concentra- tion of nitric oxide was determined by Griess Reagent in supernatant of THP-1. The content of iNOS was measured by western blotting. Results The expression of iNOS of model group was significantly higher than those of control group. Compared with model group, the ginseng could reduce expression of iNOS and concentration of NO significant- ly in THP-1. Conclusion Ginsenoside can significantly inhibit the expression of iNOS, and reduce secretions of NO, so it may provide a novel therapy for AD.
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Base de datos:
WPRIM
Idioma:
Zh
Revista:
Clinical Medicine of China
Año:
2008
Tipo del documento:
Article