Gene polymorphisms association studies in sepsis / 国际外科学杂志
International Journal of Surgery
; (12): 325-328, 2009.
Article
en Zh
| WPRIM
| ID: wpr-394849
Biblioteca responsable:
WPRO
ABSTRACT
Although significant advances have been made in both the development of therapeutic strate-gies and the understanding of pathophysiological mechanisms of sepsis, the mortality of severe sepsis and septic shock still remains unacceptably high worldwide. Current prediction models based on socio-demo-graphic and clinical risk factors fail to explain fully why a particular patient either develops or succumbs to sepsis. In recent years epidemiological studies have suggested a strong genetic relationship on the suscepti-bility and outcome of sepsis. With the completion of Human Genome Project and International HapMap Pro-ject, the identification of susceptibal genes contributing to sepsis may allow more precise use of interven-tions, such as targeted therapy of sepsis is an appealing strategy. In this review, we summarize a broad over-view of genetic nomenclature, study designs, and problems of these genetic association studies.
Texto completo:
1
Base de datos:
WPRIM
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Idioma:
Zh
Revista:
International Journal of Surgery
Año:
2009
Tipo del documento:
Article