Expression and relationship between matrix metalloproteinase-7 and E-cadherin in gastric cancer / 肿瘤研究与临床
Cancer Research and Clinic
; (6): 25-27, 2011.
Article
en Zh
| WPRIM
| ID: wpr-382939
Biblioteca responsable:
WPRO
ABSTRACT
Objective To evaluate the expressions of MMP-7, E-cadherin in gastric carcinoma, and their relationship with tumor cell invasion and metastasis. Methods The MMP-7 mRNA and E-CD mRNA were detected by hybridization in situ in 78 gastric cancer tissues. Then analyze the relationship between the expression of MMP-7, E-CD and clinicopathological features. Results The expressions of MMP-7 and Ecadherin were significantly related with the invasion and metastasis of gastric cancer cell. The E-CD mRNA expression rate in MMP-7 mRNA positive gastric carcinoma tissue was much lower than that in negative carcinoma tissue (9.09 % vs 66.70 %). Conclusion Expression of MMP-7 mRNA and E-CD mRNA is associated with invasion, metastasis. Detection of MMP-7 mRNA and E-CD mRNA in bioptic specimens may be helpful in predicting tumor metastatic and recurrent potential and prognosis for patients with gastric carcinoma.
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Base de datos:
WPRIM
Idioma:
Zh
Revista:
Cancer Research and Clinic
Año:
2011
Tipo del documento:
Article