Transdermal fentanyl for the management of cancer pain: a survey of 4492 patients / 中华肿瘤杂志
Zhonghua zhong liu za zhi
; (12): 369-372, 2005.
Article
en Zh
| WPRIM
| ID: wpr-358630
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the efficacy and adverse effects of transdermal fentanyl in management of patients with cancer pain.</p><p><b>METHODS</b>A total of 4492 patients (aged 3-90) with cancer pain were enrolled in this multicenter study. The mean age was 58.5 (3 approximately 90) years old. All patients received transdermal fentanyl. The patients were asked to record the attacks of pain, quality of life, and any side effects of the treatment.</p><p><b>RESULTS</b>Baseline mean pain intensity was 7.37. On days 1, 3, 6, 9, 15, and 30, the mean scores of pain were decreased to 4.04, 2.98, 2.52, 2.19, 1.85 and 1.61, respectively (P < 0.01). The effective rate was 96.8%. The mean doses of fentanyl were 32.37 microg/h (25-200 microg/h) on the initial day, 42.57 microg/h and 49.57 microg/h (25-225 microg/h) on days 15 and 30. The quality of life was significantly improved after treatment (P < 0.01). The common side effects were constipation (9.8%), nausea (13.6%), dizziness (6.5%), vomiting (3.9%), sedation (2.0%) and respiratory depression (0.2%). The incidence of constipation was related to age, and the incidence of vomiting and difficulty of urination was related to gender. The majority (84.5%) of patients preferred continuation of the treatment with transdermal fentanyl.</p><p><b>CONCLUSION</b>Transdermal fentanyl for the patients with cancer pain is effective, safe, convenient and can improve the quality of life. Transdermal fentanyl can be recommended as one of first-line drugs for the treatment of patients with moderate to severe cancer pain.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Dolor Intratable
/
Calidad de Vida
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Administración Cutánea
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Dimensión del Dolor
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Fentanilo
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Neoplasias del Sistema Digestivo
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Quimioterapia
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Analgésicos Opioides
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Neoplasias Pulmonares
Tipo de estudio:
Clinical_trials
Aspecto:
Patient_preference
Límite:
Adolescent
/
Adult
/
Aged
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Aged80
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Child
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Child, preschool
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Female
/
Humans
/
Male
Idioma:
Zh
Revista:
Zhonghua zhong liu za zhi
Año:
2005
Tipo del documento:
Article