Transcatheter arterial chemoembolization in the treatment of hepatocellular carcinoma / 中华肿瘤杂志
Zhonghua zhong liu za zhi
; (12): 478-482, 2005.
Article
en Zh
| WPRIM
| ID: wpr-358598
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the effect of transcatheter arterial chemoembolization (TACE) on the result and the prognosis of hepatocellular carcinoma (HCC) at systemic, cellular, genetic and molecular levels.</p><p><b>METHODS</b>Patients with histologically proven HCC were divided into two groups: 81 patients in Group A undergoing TACE before operation and 58 patients in Group B treated with surgical resection alone. The degree of apoptosis was analyzed by transferase -mediated dUTP nick end labeling (TUNEL) stain. The expressions of bcl-2, bax, p53, Ki-67 and PCNA proteins were detected by immunohistochemical method. The changes of these markers, tumor necrosis, encapsulation, volume, metastasis, recurrence and cumulative survival in each group were retrospectively analyzed.</p><p><b>RESULTS</b>The more tumor necrosis, apoptosis, encapsulation and tumor shrinkage observed, and the less recurrence resulted from TACE in group A than in group B. The cumulative 1-, 2-, and 3-year survival rates and median survival time were 84.0%, 67.9%, 40.7%, and 803.3 days in group A patients; they were 72.4%, 55.2%, 24.1%, and 742.5 days in group B patients (P < 0.05).</p><p><b>CONCLUSION</b>Preoperative transcatheter arterial chemoembolization is safe and effective as an auxiliary preparatory means before surgical treatment of hepatocellular carcinoma as it may improve the survival of HCC patients.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Pronóstico
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Terapéutica
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Protocolos de Quimioterapia Combinada Antineoplásica
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Quimioembolización Terapéutica
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Carcinoma Hepatocelular
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Arteria Hepática
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Neoplasias Hepáticas
Tipo de estudio:
Prognostic_studies
Límite:
Adult
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Aged
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Zhonghua zhong liu za zhi
Año:
2005
Tipo del documento:
Article