A study on the mechanism of bFGF promoting endothelial cells to adhere to polyurethane material / 生物医学工程学杂志
Journal of Biomedical Engineering
; (6): 386-388, 2002.
Article
en Zh
| WPRIM
| ID: wpr-357021
Biblioteca responsable:
WPRO
ABSTRACT
bFGF can promote endothelial cell to adhere to artificial polyurethane material. However the mechanism is still unclear. Here the effect of bFGF on endothelial cell expression of integrin beta 1 subunits was determined with Western Blot and image analysis method. The result reveal that the mean gray value of immunostain is 166.1 +/- 9.86 in the experimental group and 175.32 +/- 5.12 in the control group, suggest that bFGF may upregulate the endothelial cell expression of integrin beta 1 subunits. It is concluded that the bFGF may induce the overexpression of endothelial cell integrin beta 1 subunits to increase the cell adhesion onto polyurethane material. It is suggested that bFGF can be taken as an important assistant factor in accomplishment of endothelialization on artificial heart and blood vessel.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Farmacología
/
Poliuretanos
/
Porcinos
/
Endotelio Vascular
/
Adhesión Celular
/
Células Cultivadas
/
Factor 2 de Crecimiento de Fibroblastos
/
Integrina beta1
/
Biología Celular
/
Metabolismo
Límite:
Animals
Idioma:
Zh
Revista:
Journal of Biomedical Engineering
Año:
2002
Tipo del documento:
Article