Effects of naloxone on the contents of cAMP in hypothalamus and AVP in ventral septal area in fever rats / 中国应用生理学杂志
Chinese Journal of Applied Physiology
; (6): 408-410, 2009.
Article
en Zh
| WPRIM
| ID: wpr-356239
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>AIM</b>To study the effects and mechanism of naloxone on the febrile response in IL-1beta-induced fever rats.</p><p><b>METHODS</b>The fever model was established by intracerebroventricular injection of IL-1beta in rats. The effect of naloxone on the body temperature of feverrats was observed. The contents of cAMP in hypothalamus and AVP in VSA were detected.</p><p><b>RESULTS</b>Naloxone alleviated IL-1beta-induced fever and the contents of cAMP in hypothalamus and AVP in VSA were correspondingly decreased (P < 0.01).</p><p><b>CONCLUSION</b>Naloxone could inhibit IL-1beta-induced fever in rats, and the mechanism might be due to inhibiting synthesis of cAMP in hypothalamus and promoting release of AVP in VSA.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Farmacología
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Arginina Vasopresina
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Ratas Sprague-Dawley
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AMP Cíclico
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Tabique del Cerebro
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Fiebre
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Hipotálamo
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Metabolismo
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Naloxona
Límite:
Animals
Idioma:
Zh
Revista:
Chinese Journal of Applied Physiology
Año:
2009
Tipo del documento:
Article