An experimental research of neuroglobin expression changes and neural apoptosis after traumatic brain injury / 中国应用生理学杂志
Chinese Journal of Applied Physiology
; (6): 39-44, 2010.
Article
en Zh
| WPRIM
| ID: wpr-356222
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the expression changes of neuroglobin in rats with the model of diffuse traumatic brain injury and explore the relationship between the neuroglobin and neuron apoptosis in traumatic brain injury.</p><p><b>METHODS</b>The diffuse traumatic brain injury of rats was induced by the Marmarou's 'weight-drop' device. And the immunohistochemical technique was used to detect the expression changes of neuroglobin and neuron apoptosis in rat brain at different time points post-injury.</p><p><b>RESULTS</b>The expression of neuroglobin increased twice and reached peaks at 2 hours and 72 hours post-injury respectively. And the increased expression of neuroglobin from 30 minutes to 1 hour post-injury and from 48 hours to 72 hours post-injury accompanied with the decreased expression ratio of Bax to Bcl-2.</p><p><b>CONCLUSION</b>The increased expression of neuroglobin in traumatic brain injury informed us that neuroglobin had anti-apoptosis action in post-injury neuron. It could protect the neuron from traumatic stress and secondary ischemia and hypoxia insults during ultra-early and acute stages.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Patología
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Fisiología
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Encéfalo
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Lesiones Encefálicas
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Globinas
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Distribución Aleatoria
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Ratas Sprague-Dawley
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Apoptosis
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Metabolismo
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Proteínas del Tejido Nervioso
Límite:
Animals
Idioma:
Zh
Revista:
Chinese Journal of Applied Physiology
Año:
2010
Tipo del documento:
Article