Atherosclerosis and androgen levels in elderly males / 浙江大学学报·医学版
Zhejiang Daxue xuebao. Yixue ban
; (6): 547-556, 2005.
Article
en Zh
| WPRIM
| ID: wpr-355164
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To observe the relation of androgen levels and atherosclerosis (AS) in elderly males.</p><p><b>METHODS</b>Both carotid arteries and arteries of lower extremity were examined with Doppler ultrasonography. Those with arteriosclerosis and much atheromatous plaque were designated as case group, and those with normal results formed control group. Total testosterone (TT), free testosterone (FT) and estradiol (E2) were measure by radioimmunoassay, HDL-C, LDL-C, TC and TG were assayed by colorimetry, vascular endothelium growth factor (VEGF), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), intercellular adhesion molecule (sICAM-1) were determined by ELISA.</p><p><b>RESULT</b>FT was significantly lower in case group than in control group (P<0.01), no differences were found in TT, E2. HDL-C in control group was higher than that in case group (P<0.01), TC and TG were higher in case group than those in control group (P<0.05). HDL-C was correlated positively and LDL-C was negatively with FT level, while both TC and TG in case group had negative relation with FT. VEGF was higher in case group (P<0.05), and it had negative relation with FT in both groups. TNF-alpha and IL-6 were significantly higher in case group (P<0.05), and they had negative relation with FT. sICAM-1 was significantly lower in control group than it in case group (P<0.01).</p><p><b>CONCLUSION</b>The normal androgen levels, especially FT, have beneficial effect in AS development in elderly males. Low FT level may be an independent risk factor in AS development.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Testosterona
/
Sangre
/
Diagnóstico por Imagen
/
Arterias Carótidas
/
Factores de Riesgo
/
Ultrasonografía Doppler
/
Aterosclerosis
/
Andrógenos
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Risk_factors_studies
Límite:
Aged
/
Humans
/
Male
Idioma:
Zh
Revista:
Zhejiang Daxue xuebao. Yixue ban
Año:
2005
Tipo del documento:
Article