Autologous skeletal myoblast transplantation improves hemodynamics dogs with chronic heart failure dogs / 南方医科大学学报
Journal of Southern Medical University
; (12): 475-477, 2010.
Article
en Zh
| WPRIM
| ID: wpr-355097
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To test the effects of autologous skeletal myoblast transplantation on the hemodynamics in dogs with coronary microembolization-induced chronic heart failure (CHF).</p><p><b>METHODS</b>CHF models were successfully induced in 19 dogs and divided into ASMT group (n=9) and control group (n=10). The myoblasts were injected into the embolized region in the 9 dogs of the ASMT group, and saline was injected in the control dogs, and the hemodynamics of the dogs were evaluated 5 weeks after the injections.</p><p><b>RESULT</b>Compared with saline injection, ASMT significantly increased dP/dtmax, MAP and LVSP (P<0.05) and decreased LVEDP (P<0.05) 5 weeks after myoblast transplantation. Desmin and Brd-U immunofluorescent staining showed myoblast survival at the injected sites in the dogs.</p><p><b>CONCLUSION</b>ASMT provides mild improvements in the hemodynamics of dogs with CHF.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Terapéutica
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Trasplante
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Trasplante Autólogo
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Enfermedad Crónica
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Mioblastos Esqueléticos
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Insuficiencia Cardíaca
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Hemodinámica
Límite:
Animals
Idioma:
Zh
Revista:
Journal of Southern Medical University
Año:
2010
Tipo del documento:
Article