Effects of alpha lipoic acid on hypothalamus-pituitary-adrenal axis in rats / 南方医科大学学报
Journal of Southern Medical University
; (12): 664-667, 2010.
Article
en Zh
| WPRIM
| ID: wpr-355048
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the functional and ultramicrostructural effects of alpha lipoic acid on hypothalamus-pituitary-adrenal (HPA) axis in normal and diabetic rats.</p><p><b>METHODS</b>Using radioimmunoassay we observed the effects of three doses (1, 20, and 100 mg/kg) of alpha lipoic acid injected intraperitoneally for 3 weeks on the plasma levels of CRH, ACTH and COR in normal and diabetic rats. The ultramicrostructural changes of the hypophysis and pituitary gland after alpha lipoic acid treatment were observed under transmission electron microscope.</p><p><b>RESULTS</b>Compared with the control group, CRH level in lipoicin-treated normal and diabetic rats was significantly reduced (P<0.05). ACTH level of the 3 lipoicin doses groups of normal rats decreased, and a significant reduction occurred in medium-dose lipoicin group of diabetic rats (P<0.05). COR level showed the same changes as CRH level in normal rats, but decreased significantly in high- and medium-dose lipoicin groups of diabetic rats. Lipoicin treatment produced no apparent effect on the ultramicrostructures of the hypophysis and pituitary gland cells, which were the targets of diabetic lesions with low metabolism functions. Lipoicin treatment obviously enhanced the hypophysis and pituitary gland cell metabolism function to resist diabetic oxidative stress.</p><p><b>CONCLUSION</b>Lipoicin can inhibit the HPA axis directly or indirectly in normal and diabetic rats.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Patología
/
Farmacología
/
Fisiología
/
Sistema Hipófiso-Suprarrenal
/
Diagnóstico por Imagen
/
Distribución Aleatoria
/
Ácido Tióctico
/
Ultrasonografía
/
Ratas Sprague-Dawley
/
Diabetes Mellitus Experimental
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
Idioma:
Zh
Revista:
Journal of Southern Medical University
Año:
2010
Tipo del documento:
Article