Expressions of interleukin 18 and prostaglandin E2 and their correlation in the synoviocytes of patients with osteoarthritis / 南方医科大学学报
Journal of Southern Medical University
; (12): 731-733, 2010.
Article
en Zh
| WPRIM
| ID: wpr-355032
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the expression of interleukin 18 (IL-18) and prostaglandin E2 (PGE2) and their relationship in the synoviocytes of patients with osteoarthritis (OA).</p><p><b>METHODS</b>The synovial tissues were obtained from 30 OA patients to isolate the synoviocytes for primary culture. The concentrations of IL-18 and PGE2 in the supernatants of synoviocyte culture were measured by enzyme-linked immunosorbent assay (ELISA).</p><p><b>RESULTS</b>The concentration of IL-18 averaged 51.559-/+27.614 pg/ml and PGE2 327.036-/+333.561 pg/ml in the supernatant of the synoviocytes. A significant positive correlation was noted between their expressions (r=0.863, P<0.01).</p><p><b>CONCLUSION</b>IL-18 may induce the production of PGE2, and their interactions they may play an important role in the pathogenesis of OA.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Osteoartritis
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Patología
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Membrana Sinovial
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Dinoprostona
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Células Cultivadas
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Interleucina-18
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Metabolismo
Límite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Journal of Southern Medical University
Año:
2010
Tipo del documento:
Article