Genetic diversity of adenoviruses in bats of China / 病毒学报
Chinese Journal of Virology
; (6): 403-408, 2012.
Article
en Zh
| WPRIM
| ID: wpr-354717
Biblioteca responsable:
WPRO
ABSTRACT
Adenovirus remains a significant threat to public health. Recent studies showed that bats can harbor diverse adenoviruses. To further investigate the distribution and genetic diversity of bat adenoviruses in China, we collected throat and anal swab samples of 11 bat species from 6 provinces of China, including Beijing, Hunan, Jiangxi, Yunnan, Guizhou and Hainan. Nested PCR was used to identify potential bat adenoviruses from the samples, and positive results were cloned and sequenced for genetic diversity study. In addition, nucleotide sequence alignments based on corresponding amino acid sequence similarities were used for phylogenetic analyses. Our results showed that about 20% of bat species in China are positive to adenoviruses, and Myotis ricketti is likely to be the most important host of bat adenoviruses in all locations. Moreover, we identified two diverse sequences of bat adenoviruses from the same sample of Ia io in Guizhou province of China. In general, the average nucleotide and amino acid sequence similarities of the conserved region of DNA polymerases of bat adenoviruses are 66.6% and 74.7%, respectively. The differences between bat species and their residences environments may have driven the adaptive evolution of the viruses, leading to the genetic diversity of the bat adenoviruses.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Filogenia
/
Fisiología
/
Variación Genética
/
Virología
/
Adenoviridae
/
China
/
Quirópteros
/
Clasificación
/
Especificidad del Huésped
/
Genética
Límite:
Animals
País/Región como asunto:
Asia
Idioma:
Zh
Revista:
Chinese Journal of Virology
Año:
2012
Tipo del documento:
Article