Diagnostic values of prealbumin and retinol-binding protein for liver damage caused by different degrees of neonatal asphyxia / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 337-341, 2017.
Article
en Zh
| WPRIM
| ID: wpr-351349
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the diagnostic values of prealbumin (PAB) and retinol-binding protein (RBP) for liver damage caused by mild or severe asphyxia.</p><p><b>METHODS</b>A retrospective analysis was performed on 185 neonates (including 84 premature infants and 101 full-term infants) with asphyxia. Based on the Apgar score, they were divided into two groups: mild asphyxia group (n=150) and severe asphyxia group (n=35). The levels of PAB, RBP, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) were measured and compared. Their diagnostic values for liver damage were evaluated by ROC curve analysis.</p><p><b>RESULTS</b>The premature infants in the severe asphyxia group had significantly higher AST level and significantly lower levels of PAB and RBP than those in the mild asphyxia group (P<0.05). The full-term infants in the severe asphyxia group had a significantly lower PAB level than those in the mild asphyxia group (P<0.05). After treatment, the PAB level was significantly improved in the premature infants in the severe asphyxia group and in the full-term infants in both mild and severe asphyxia group (P<0.05). The full-term infants in the mild asphyxia groups also showed a significant improvement in AST level (P<0.05). The ROC curve analysis showed that PAB had a good sensitivity and specificity for identifying liver damage caused by mild or severe asphyxia in full-term and preterm infants.</p><p><b>CONCLUSIONS</b>PAB can be used as an indicator of liver damage caused by asphyxia in neonates, and can be used to assess the degree of asphyxia.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Aspartato Aminotransferasas
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Asfixia Neonatal
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Sangre
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Prealbúmina
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Proteínas de Unión al Retinol
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Albúmina Sérica
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Diagnóstico
/
Hepatopatías
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Female
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Humans
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Male
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Newborn
Idioma:
Zh
Revista:
Chinese Journal of Contemporary Pediatrics
Año:
2017
Tipo del documento:
Article