Effect of pre-procedural statin therapy on myocardial no-reflow following percutaneous coronary intervention: a meta analysis / 中华医学杂志(英文版)
Chin. med. j
; Chin. med. j;(24): 1755-1760, 2013.
Article
en En
| WPRIM
| ID: wpr-350430
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>BACKGROUND</b>Successful revascularization of coronary artery disease, especially ST-elevation myocardial infarction (STEMI), does not always mean optimal myocardial reperfusion in a portion of patients because of no-reflow phenomenon. We hypothesized that statins might attenuate the incidence of myocardial no-reflow when used before percutaneous coronary intervention (PCI). The purpose of this study was to summarize the evidence of pre-procedural statin therapy to reduce myocardial no-reflow after PCI.</p><p><b>METHODS</b>We searched the MEDLINE, Cochrane, and clinicaltrials.gov databases from inception to October 2012 for clinical trials that examined statin therapy before PCI. We required that studies initiated statins before PCI and reported myocardial no-reflow. A DerSimonian-Laird model was used to construct random-effects summary risk ratios.</p><p><b>RESULTS</b>In all, 7 studies with 3086 patients met our selection criteria. The use of pre-procedural statins significantly reduced post-procedural no-reflow by 4.2% in all PCI patients (risk ratio (RR) 0.56, 95% confidence interval (CI) 0.35 to 0.90, P = 0.016), and attenuated by 5.0% in non-STEMI patients (RR 0.41, 95% CI 0.18 to 0.94, P = 0.035). This benefit was mainly observed in the early or acute intensive statin therapy populations (RR 0.43, 95% CI 0.26 to 0.71, P = 0.001).</p><p><b>CONCLUSIONS</b>Acute intensive statin therapy before PCI significantly reduces the hazard of post-procedural no-reflow phenomenon. The routine use of statins before PCI should be considered.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Guías de Práctica Clínica como Asunto
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Inhibidores de Hidroximetilglutaril-CoA Reductasas
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Usos Terapéuticos
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Fenómeno de no Reflujo
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Intervención Coronaria Percutánea
Tipo de estudio:
Guideline
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Prognostic_studies
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Systematic_reviews
Límite:
Aged
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Female
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Humans
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Male
Idioma:
En
Revista:
Chin. med. j
Año:
2013
Tipo del documento:
Article