Quality evaluation of artificial musk based on its inhibitory effect on cyclooxygenase-2 / 药学学报
Yao Xue Xue Bao
; (12): 438-442, 2011.
Article
en Zh
| WPRIM
| ID: wpr-348937
Biblioteca responsable:
WPRO
ABSTRACT
The inhibitory ratio (1%) of artificial musk on cyclooxygenase-2 (COX-2) was determined by enzyme immunoassay (EIA). The dose-effect relationship between concentrations of artificial musk and 1% was established. It was found that artificial musk had obvious inhibitory action on COX-2. The concentration for 50% of maximum inhibitory effect (IC50) was about 2.26 mg x mL(-1). There was a good relationship between the logarithm concentrations of artificial musk and 1% when the concentrations of artificial musk ranged from 0.31-20.0 mg x mL(-1). The results indicated that this EIA method could be applied to evaluate the anti-inflammatory activity of artificial musk quickly, conveniently, sensitively and exactly. This paper provided a novel method and foundational research for the bioassay of artificial musk.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Farmacología
/
Ácidos Grasos Monoinsaturados
/
Técnicas para Inmunoenzimas
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Concentración 50 Inhibidora
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Relación Estructura-Actividad Cuantitativa
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Ciclooxigenasa 2
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Inhibidores de la Ciclooxigenasa 2
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Metabolismo
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Métodos
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Antiinflamatorios
Idioma:
Zh
Revista:
Yao Xue Xue Bao
Año:
2011
Tipo del documento:
Article